LIPID-POLYMER HYBRID NANOPARTICLES AS AN EMERGING DRUG DELIVERY SYSTEMS: A REVIEW

Abstract:

Liposomes and polymeric nanoparticles have been proposed as drug carriers to improve the efficacy of medicines, but some issues such as instability, poor membrane permeability, introduced Lipid-polymer hybrid nanoparticles (LPHNPs) as new generation nano molecules, which contains both liposomes and polymeric nanoparticles (NPs), where the polymer core is covered by a lipid layer, which exhibit synergic characteristics of both polymeric nanoparticles and liposomes, mainly physical stability.The hybrid rigid design can provide several advantages, including controlled particle size, high drug loading with single and combinational drugs, surface functionality with a variety of ligands, genes, proteins, peptides, vaccines, diagnostic imaging agents, and prolonged release with high blood circulation for an extended period of time. So, LPHNPs have been validated as a better drug delivery platform, with superior in-vivo cellular effectiveness of several medicines when compared to polymeric nanoparticles and liposomes. This study provides an overview of lipid-polymer hybrid nanoparticles (LPHNPs), numerous types of LPHNPs and their benefits, multiple methods of manufacture using contemporary technologies for easy manufacturing on the shop floor, their physiochemical, in vitro, and in vivo assessment, and their use in medicine. Keywords: Polymeric nanoparticles, Liposomes, Lipid polymer hybrid nanoparticles, bioavailability; pharmacokinetics.

View PDF