Advancements in Solubility Enhancement of BCS Class-II Drugs through Solid Dispersion: A Comprehensive Review

Abstract:

The solubility and dissolution rate of poorly water-soluble drugs, categorized under Biopharmaceutics Classification System (BCS) Class II, pose significant challenges in pharmaceutical formulation development. Solid dispersion, a promising technique, has gained substantial attention for enhancing the solubility and thereby improving the bioavailability of such drugs. This review aims to provide a comprehensive overview of recent advancements in the field of solid dispersion-based solubility enhancement of BCS Class II drugs. The article begins with an introduction to BCS classification and the significance of solubility enhancement in drug formulation. It then delves into the principles underlying solid dispersion, discussing various types of carriers, methods of preparation, and factors influencing the formulation process. Moreover, it highlights the mechanisms involved in solubility enhancement within solid dispersions, including particle size reduction, increased wettability, and formation of amorphous drug-carrier systems. The review discusses the impact of formulation variables, such as drug-carrier ratio, method of preparation, and processing conditions, on the solubility enhancement efficacy of solid dispersions. KEYWORDS: Solubility, Solid Dispersion, Carriers.

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