Exploring Dry Emulsion Tablets through Lyophilization: A Review

Abstract:

The goal of the dry emulsion formulation is to lessen
adverse effects and increase medicinal ingredients' absorption. Because they
are formulations that are both physically and microbiologically stable, dry
emulsions are appealing. For lipophilic and poorly soluble medicinal compounds,
they offer a viable oral drug delivery strategy. Liquid o/w emulsions with a
solid carrier in the aqueous phase are dried to create dry emulsions. The bulk
and mass of the dry emulsions are provided by the solid carrier. Spray drying,
lyophilization, and rotary evaporation are methods that can be used to create
dry emulsions. In this review article the lyophilization process is explored.
Lyophilization-produced dry emulsion tablets present a novel method for
improving the solubility and bioavailability of poorly soluble medications.
This formulation method entails lyophilization to produce a stable dry emulsion
solution, which is then compressed into tablet form. Comparing the resultant
tablets to traditional liquid emulsions, the former show better stability and
drug dissolving characteristics. This review emphasises how dry emulsion pills
are a viable solution to the problems associated with poorly soluble
medications, providing better therapeutic results and patient compliance.

Keywords: Dry emulsion tablet, lipophilic medications,
Lyophilization

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